Endocrine Abstracts

Several studies demonstrated that the thyroid hormones (TH) downregulate the transcriptional rate of beta and alpha TSH subunits. Recent data showed that T3 also acts posttranscriptionally reducing the polyadenylation and translational rate of the beta TSH mRNA, when acutely administered to thyroidectomized (Tx) rats. This study aimed to investigate whether similar effects occur for the alpha subunit synthesis after acute administration of T3 or T4</...